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Anabolic Steroids In Women Title: Understanding Anabolic Steroids – Uses, Effects, and Risks --- What Are Anabolic Steroids? Anabolic steroids are synthetic compounds modeled after the male sex hormone testosterone. They promote muscle growth (anabolism) by increasing protein synthesis in cells. The main types used medically include: Oxandrolone – often prescribed for weight loss after surgery or severe injury. Nandrolone decanoate – used to treat anemia and bone loss, especially in patients with chronic diseases. While they have legitimate therapeutic roles, many athletes and bodybuilders use them outside medical supervision to enhance performance or physique. How Do They Work? Binding to Androgen Receptors Steroids enter cells and attach to androgen receptors in the nucleus. Gene Activation This complex acts like a transcription factor, turning on genes that encode proteins for muscle growth, red‑cell production, and bone formation. 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Experimental Design to Validate the Model 6.1 In‑Vitro Validation Cell Lines: - Human hepatocytes (HepG2 or primary human hepatocytes) for metabolism. - Breast cancer cells (MCF‑7) for downstream effects. Treatments: - Vary concentrations of testosterone and 4‑OH‑testosterone (e.g., 0, 1, 10, 100 nM). - Include inhibitors/inducers of CYP3A4 to modulate metabolism. Assays: - LC‑MS/MS for metabolite profiling. - qPCR and Western blotting for target gene expression (e.g., MMPs, HER2). - Proliferation assays (MTT), migration/invasion assays (Transwell). Data Analysis: - Correlate intracellular concentrations of metabolites with functional readouts. 5. Expected Outcomes & Impact Quantitative understanding of how the metabolic profile of androsterone, testosterone, and progesterone shapes their pharmacological effects. Identification of key metabolites that drive therapeutic or adverse responses. Insights into potential drug–hormone interactions (e.g., enzyme induction/inhibition). 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